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Study identifier: NCT06461208 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

A PROspective Faecal MIcrobiota tranSplantation Trial to Improve outcomEs in Patients With Cirrhosis

Condition: Liver Cirrhosis  ·  Sponsor: King's College London

PhasePhase 3
Planned participants300
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

A feasibility trial called PROFIT has previously shown that FMT administered endoscopically into the jejunum in patients with cirrhosis is safe and feasible and have identified some potential mechanisms of action that warrant further interrogation. The aim of the PROMISE Trial is to evaluate the efficacy and mechanisms of action of encapsulated FMT (versus placebo) to reduce infection and mortality in patients with alcohol-related and metabolic dysfunction-Associated Steatotic Liver (MASLD) cirrhosis.

This description comes directly from the study's public registry record.

Talk to the study team

Sue Cheung  ·  020 7848 0532  ·  PROMISE@kcl.ac.uk

Debbie Shawcross  ·  020 3299 3713  ·  debbie.shawcross@kcl.ac.uk

Always discuss trial participation with your own doctor first.

Locations (23)

Basildon University HospitalBasildon, United KingdomRecruiting
Royal Bournemouth HospitalBournemouth, United KingdomRecruiting
Southmead HospitalBristol, United KingdomRecruiting
Bristol Royal InfirmaryBristol, United KingdomRecruiting
Broomfield HospitalChelmsford, United KingdomRecruiting
Royal Derby HospitalDerby, United KingdomRecruiting
Ninewells HospitalDundee, United KingdomRecruiting
Queen Elizabeth HospitalGateshead, United KingdomRecruiting
Glasgow Royal InfirmaryGlasgow, United KingdomRecruiting
Queen Elizabeth University HospitalGlasgow, United KingdomRecruiting
University Hospital HairmyresGlasgow, United KingdomRecruiting
Hull Royal InfirmaryHull, United KingdomRecruiting

+ 11 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT06461208