● Recruiting

Study to Assess Safety, Tolerability and Activity of DSB2455 in Participants With Advanced Malignancies

Condition: Advanced Cancers (Breast, Ovarian, mCRPC, Pancreatic Ductal Adenocarcinoma (PDAC), Brain Mets) With Specific Mutations (Homologous Recombination Deficiency) · Sponsor: Duke Street Bio Ltd

PhasePhase 1

Planned participants180

Who can joinAll sexes, 18 Years to no upper limit

Healthy volunteersNo

About this study

Open label, multi-centre, Phase Ia/b adaptive design study with an initial 2-stage Dose Escalation Phase followed by a Dose Expansion Phase.

This description comes directly from the study's public registry record.

Talk to the study team

Duke Street Bio · +44 (0)203 890 8710 · clinicaltrials@dukesb.com

Always discuss trial participation with your own doctor first.

Locations (18)

Yale Cancer Center - Yale New Haven Hospital	New Haven, Connecticut, United States	Recruiting
Tisch Cancer Institute Icahn School of Medicine at Mount Sinai	New York, New York, United States	Recruiting
The University of Texas M. D. Anderson Cancer Center	Houston, Texas, United States	Recruiting
Institut Bergonie	Bordeaux, France	Recruiting
Institut Godinot	Reims, France	Recruiting
Orszagos Onkologiai Intezet	Budapest, Hungary	Recruiting
Centrum Terapii Wspolczesnej	Lodz, Poland	Recruiting
Uniwersytecki Szpital Kliniczny w Poznaniu	Poznan, Poland	Recruiting
START La Rioja, Hospital Universitario San Pedro	Logroño, La Rioja, Spain	Recruiting
Hospital Universitari Vall d'Hebron	Barcelona, Spain	Recruiting
START Barcelona, CIOCC, Hospital Universitario Nou Delfos	Barcelona, Spain	Recruiting
Hospital Universitario Reina Sofía	Córdoba, Spain	Recruiting

+ 6 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT06458712