Condition: Schizophrenia · Treatment Resistant Schizophrenia · Sponsor: Central Institute of Mental Health, Mannheim
Schizophrenia is one of the most severe and costliest mental disorders in terms of human suffering and societal expenditure. About 15-30% of patients do not respond to all known antipsychotics, including clozapine, the current gold-standard in these cases. Hence, a recent Cochrane review stated that the quality of the existing studies is too poor to recommend any intervention in addition to clozapine and that new, randomized controlled trials independent from the pharmaceutical industry need to be performed to substantially improve patient care. Although electroconvulsive therapy (ECT) was initially used to treat schizophrenia, it is nowadays by far underused in the therapy of schizophrenia in many countries. ECT is well known to be highly effective in clozapine-treatment-resistant schizophrenia (CRS), and synergistic effects of clozapine and ECT have been demonstrated. However, relapse rates after successful courses of ECT are still very high, and evidence for maintenance ECT (mECT) in CRS is scarce at best. In a multi-center trial the investigators aim to examine the effectiveness of mECT in treatment-resistant patients with schizophrenia who improved after a course of routine ECT. If mECT will lead to a later timepoint of relapse and/or to a higher proportion of relapse-free patients compared to those undergoing treatment as usual, this trial would have an enormous impact on therapeutic strategies for "treatment-resistant" patients and would induce a profound change of cur…
This description comes directly from the study's public registry record.
Alexander Sartorius, Prof · +49-621-1703 · alexander.sartorius@zi-mannheim.de
Christian R Wolf, Prof · +49-6221-56 · Christian.Wolf@med.uni-heidelberg.de
Always discuss trial participation with your own doctor first.
| Dept. of Psychiatry, RWTU Aachen | Aachen, Germany | Not Yet Recruiting |
| Dept. of Psychiatry, University of Augsburg | Augsburg, Germany | Not Yet Recruiting |
| Klinik für Psychiatrie, Göppingen | Göppingen, Germany | Not Yet Recruiting |
| Departmet of Psychiatry, University Medical Center Göttingen | Göttingen, Germany | Not Yet Recruiting |
| Dept. of Psychiatry, Hannover Medical School | Hanover, Germany | Not Yet Recruiting |
| Universitätsklinikum Heidelberg, Klinik für Allgemeine Psychiatrie | Heidelberg, Germany | Not Yet Recruiting |
| Zentrum für Psychische Gesundheit | Ingolstadt, Germany | Not Yet Recruiting |
| Dept. of Psychiatry, University Mainz | Mainz, Germany | Not Yet Recruiting |
| Department of Psychiatry and Psychotherapy, Central Institute of Mental Health (CIMH) | Mannheim, Germany | Recruiting |
| Dept. of Psychiatry, LMU München | München, Germany | Not Yet Recruiting |
| Clinic for Psychiatry, Saarbrücken | Saarbrücken, Germany | Not Yet Recruiting |
| Klinik für Psychiatrie, Siegen | Siegen, Germany | Not Yet Recruiting |
+ 2 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT06456983