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Study identifier: NCT06456593 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Efficacy and Safety of Obefazimod in Subjects With Moderately to Severely Active Crohn's Disease

Condition: Moderately to Severely Active Crohn Disease  ·  Sponsor: Abivax S.A.

PhasePhase 2
Planned participants212
Who can joinAll sexes, 18 Years to 75 Years
Healthy volunteersNo

About this study

This study has 3 treatment phases, a 12-Week Induction Phase, a 40-Week Maintenance Phase, and a 48-Week Extension Phase. The objective is to evaluate the efficacy and safety of obefazimod compared to placebo as induction and maintenance therapy in subjects with moderately to severely active CD after inadequate response (no response, loss of response, or intolerance) to conventional therapies and/or advanced therapies. The primary objective for the 48-Week Extension Phase is to evaluate the safety and tolerability of obefazimod compared with placebo in subjects who are enrolled in the Extension Phase.

This description comes directly from the study's public registry record.

Talk to the study team

Study Director  ·  +33 (0) 1 53 83 09 63  ·  info@abivax.com

Always discuss trial participation with your own doctor first.

Locations (149)

IMC Gulf Coast Gastroenterology, PCFairhope, Alabama, United StatesNot Yet Recruiting
Scottsdale Gastroenterology SpecialistsScottsdale, Arizona, United StatesNot Yet Recruiting
GI Alliance -GurneeSun City, Arizona, United StatesRecruiting
Hoag HospitalIrvine, California, United StatesNot Yet Recruiting
United Medical DoctorsMurrieta, California, United StatesRecruiting
Peak Gastroenterology AssociatesColorado Springs, Colorado, United StatesRecruiting
Clinical Research Of Brandon, LLCBrandon, Florida, United StatesRecruiting
West Central Gastroenterology d/b/a Gastro FloridaClearwater, Florida, United StatesRecruiting
Auzmer ResearchLakeland, Florida, United StatesRecruiting
Research Associates of South Florida, LLCMiami, Florida, United StatesRecruiting
Wellness Clinical ResearchMiami Lakes, Florida, United StatesNot Yet Recruiting
Advanced Research Institute, Inc.New Port Richey, Florida, United StatesRecruiting

+ 137 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT06456593