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Study identifier: NCT06455605 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

D2C7-IT + 2141-V11 Combination Post-resection in rGBM

Condition: Recurrent Glioblastoma IDH Wildtype  ·  Sponsor: Darell Bigner

PhasePhase 1
Planned participants46
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The purpose of this study is to assess the safety and efficacy of the combination of D2C7-IT+2141-V11 administered in the non-enhancing tumor of patients with resected recurrent glioblastoma (rGBM) via convection enhanced delivery (CED), followed by subcutaneous cervical perilymphatic injections (CPLIs) of 2141-V11 2 and 4 weeks post infusion, then every 3 weeks for a year, and every 4-6 weeks thereafter if patients benefit from therapy.

This description comes directly from the study's public registry record.

Talk to the study team

Annick Desjardins, MD  ·  919-684-5301  ·  dukebrain1@dm.duke.edu

Stevie Threatt  ·  919-684-5301  ·  dukebrain1@dm.duke.edu

Always discuss trial participation with your own doctor first.

Locations (1)

Duke University Medical CenterDurham, North Carolina, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT06455605