Condition: Advanced Pancreatic Adenocarcinoma · Stage III Pancreatic Cancer AJCC v8 · Stage IV Pancreatic Cancer AJCC v8 · Sponsor: City of Hope Medical Center
This phase Ib trial tests the safety, side effects, and best dose of leflunomide in combination with gemcitabine in treating patients with pancreatic cancer that may have spread from where it first started to nearby tissue, lymph nodes, or distant parts of the body (advanced) and cannot be removed by surgery (unresectable). Improving the effectiveness of gemcitabine without increasing side effects could lead to a greater impact for pancreatic cancer patients' survival and quality of life. Gemcitabine is commonly used as a first-line chemotherapy treatment for pancreatic cancer. Leflunomide is a drug approved for use against rheumatoid arthritis that is being looked at as a cancer treatment option. It has shown promising results when combined with gemcitabine. Giving gemcitabine in combination with leflunomide may be safe and effective in treating patients with advanced unresectable pancreatic cancer.
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| City of Hope Medical Center | Duarte, California, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06454383