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Study identifier: NCT06452719 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Letrozole and Misoprostol for Early Pregnancy Loss Management

Condition: Early Pregnancy Loss · Miscarriage in First Trimester · Miscarriage  ·  Sponsor: University of Pennsylvania

PhasePhase 2
Planned participants30
Who can joinFemale, 18 Years to no upper limit
Healthy volunteersNo

About this study

A pilot cohort study to preliminarily investigate the efficacy of pretreatment with letrozole 10 mg daily for three consecutive days followed by treatment with misoprostol 800 mcg vaginally for medical management of early pregnancy loss in a US population. Patients will be followed to assess efficacy of this treatment regimen, as well as additional interventions needed, side effects, adverse events, and patient acceptability.

This description comes directly from the study's public registry record.

Talk to the study team

Arden McAllister, MPH  ·  215-785-8030  ·  arden.mcallister@pennmedicine.upenn.edu

Always discuss trial participation with your own doctor first.

Locations (1)

PEACE / Penn MedicinePhiladelphia, Pennsylvania, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT06452719