Condition: Locoregional Recurrence · Breast Cancer · Re-irradiation · Sponsor: Amsterdam UMC, location VUmc
In the Netherlands, breast cancer patients with locoregional recurrence (LRR) and intermediate- and high-risk factors are treated with surgery with or without postoperative re-irradiation with or without hyperthermia. Retrospective studies showed that 3-year locoregional control after postoperative re-irradiation with hyperthermia was 68-83%, and severe toxicity in up to 40% of LRR patients. Unfortunately, no prospective (randomized) data are available on clinical outcomes. Consequently, variation exists in hyperthermia-treatment and re-irradiation schedules. Prospective real-world data on oncological outcomes, toxicity and quality of life is highly needed for shared decision-making between patients and professionals. These data will be used in the design of a future randomized trial in high-risk LRR patients.
This description comes directly from the study's public registry record.
Lisca Wurfbain, MD · +31 6-25414750 · l.f.wurfbain@amsterdamumc.nl
Desiree Van Den Bongard, Dr · +31 6-25414750 · h.j.vandenbongard@amsterdamumc.nl
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| Amsterdam UMC | Amsterdam, Netherlands | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06452485