Condition: Mitochondrial Diseases · Maternally Inherited Diabetes and Deafness (MIDD) · Mitochondrial Encephalomyopathy, Lactic Acidosis and Stroke-like Episodes (MELAS) · Sponsor: Khondrion BV
The KHENERFIN study aims to determine whether the study medicine, sonlicromanol, is able to reduce symptoms of fatigue and the impact of fatigue on daily life, and whether sonlicromanol is able to improve physical abilities of people like balance control and lower limb skeletal muscle strength in people with mitochondrial disease. In this study, the effects of sonlicromanol are compared against a placebo, a tablet identical in appearance and taste but without the active drug. Participants take either sonlicromanol or placebo twice daily for a treatment duration of 52 weeks. In addition to these primary objectives, the study evaluates the efficacy of sonlicromanol on secondary and exploratory outcomes, as well as its safety and tolerability after one year of treatment.
This description comes directly from the study's public registry record.
Jasper Levink, MSc. · +31 24 7635000 · Khenerfin@khondrion.com
G. Ruiterkamp, MSc. · +31 24 7635000 · Khenerfin@khondrion.com
Always discuss trial participation with your own doctor first.
| Massachusetts General Hospital | Boston, Massachusetts, United States | Not Yet Recruiting |
| Cleveland Clinic Neurological Institute Mellen Center | Cleveland, Ohio, United States | Not Yet Recruiting |
| The University of Texas Health Science Center at Houston | Houston, Texas, United States | Recruiting |
| Rigshospitalet, University of Copenhagen | Kopenhagen, Region Sjælland, Denmark | Not Yet Recruiting |
| CHU de Bordeaux - Hôpital Pellegrin Service Gynecologie Obstetrique | Bordeaux, Gironde, France | Not Yet Recruiting |
| Groupe Hospitalier Pitie-Salpetriere - Charles-Foix Clinical Investigation Center Paris-Est | Paris, Paris, France | Not Yet Recruiting |
| Klinikum der Universität München Friedrich-Baur-Institut | München, Germany | Recruiting |
| Fondazione IRCCS Istituto Neurologico Carlo Besta | Milan, Italy | Recruiting |
| Radboud University Medical Center | Nijmegen, Gelderland, Netherlands | Recruiting |
| University College London Hospitals NHS Foundation Trust National Hospital for Neurology and Neurosurgery | London, Greater London, United Kingdom | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06451757