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Study identifier: NCT06450470 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Use of a Freeze-dried Amniotic Membrane Post Crosslinking in Subjects With Progressive Keratoconus

Condition: Progressive Keratoconus  ·  Sponsor: TBF Genie Tissulaire

PhasePhase 3
Planned participants116
Who can joinAll sexes, 18 Years to 65 Years
Healthy volunteersNo

About this study

Crosslinking is a therapeutic technique used to increase the rigidity of the cornea in order to slow or stop progression of keratoconus. The main complication of the treatment of keratoconus by crosslinking is postoperative pain due to the removal of the corneal epithelium. Currently, the management of pain is done through the administration of artificial tears and paracetamol. The amniotic membrane is a biological tissue used in ophthalmology to treat injuries of the surface of the eye. It has healing and analgesic properties. The objective of this multicenter randomized study is to evaluate the benefit of placing an amniotic membrane on the eye post-crosslinking to reduce pain and promote corneal healing.

This description comes directly from the study's public registry record.

Talk to the study team

Laurence BARNOUIN, MD  ·  0472686909  ·  laurence.barnouin@tbf-lab.com

Justine BOSC, MSc  ·  4 72 68 69 11  ·  justine.bosc@tbf-lab.com

Always discuss trial participation with your own doctor first.

Locations (9)

CHU de BrestBrest, FranceRecruiting
Hospices Civils de LyonLyon, FranceRecruiting
Assistance Publique - Hôpitaux de MarseilleMarseille, FranceRecruiting
CHU de MontpellierMontpellier, FranceRecruiting
CHU de NantesNantes, FranceNot Yet Recruiting
Hôpital National de la Vision des Quinze-VingtsParis, FranceRecruiting
CHU de Saint-EtienneSaint-Priest-en-Jarez, FranceRecruiting
Hôpitaux Universitaires de StrasbourgStrasbourg, FranceRecruiting
CHU de ToulouseToulouse, FranceRecruiting

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Source record: clinicaltrials.gov/study/NCT06450470