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Study identifier: NCT06450314 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Decreasing Treatment for Metastatic HER2-Positive Breast Cancer With Undectable Cancer Levels in Blood Tests.

Condition: Metastatic Breast Cancer · HER2-positive Breast Cancer  ·  Sponsor: UNICANCER

PhasePhase 2
Planned participants170
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

Heroes is a multicentre, national, non-randomized, open-label, phase 2 study. The goal of this clinical trial is to evaluate the feasibility of therapeutic de-escalation in HER2-positive metastatic breast cancer with disease controlled after 2 years of maintenance treatment with anti-HER2 targeted therapy AND ctDNA negative testing. The main question it aims to answer is : • Is it possible to identify patients for whom temporary or permanent discontinuation of treatment is possible without impacting prognosis?

This description comes directly from the study's public registry record.

Talk to the study team

Clara Guyonneau, PharmD  ·  +33 (0) 1 44.23.04.65  ·  c-guyonneau@unicancer.fr

Thibault De la Motte Rouge, MD  ·  t.delamotterouge@rennes.unicancer.fr

Always discuss trial participation with your own doctor first.

Locations (1)

Centre Eugène marquisRennes, FranceRecruiting

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Source record: clinicaltrials.gov/study/NCT06450314