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Study identifier: NCT06447376 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Study of Cytokine Release Syndrome Prophylaxis and Treatment With Siltuximab Prior to Epcoritamab

Condition: Non-Hodgkin Lymphoma · Cytokine Release Syndrome  ·  Sponsor: Taylor Brooks

PhasePhase 1
Planned participants20
Who can joinAll sexes, 18 Years to 65 Years
Healthy volunteersNo

About this study

The goal of this clinical trial is to is to determine the safety, feasibility and efficacy of siltuximab prophylaxis of cytokine release syndrome and neurotoxicity occurring after epcoritamab subcutaneous administration for participants with large b-cell lymphoma (DLBCL) or follicular lymphoma (FL). Participants will receive siltuximab, prior to the injection of epcoritamab. Epcoritamab is administered in 28 day cycles for one year. After this injection, the physician will continue to watch participants for side effects and follow the condition for a minimum of 60 days.

This description comes directly from the study's public registry record.

Talk to the study team

Taylor Brooks, MD  ·  1-866-223 8100  ·  TaussigResearch@ccf.org

Always discuss trial participation with your own doctor first.

Locations (1)

Cleveland Clinic Taussig Cancer Institute, Case Comprehensive Cancer CenterCleveland, Ohio, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT06447376