Condition: Acute Kidney Injury · Dialysis; Complications · Sponsor: University of Alberta
An estimated 10-15% of critically ill patients with acute kidney failure in the intensive care unit receive acute dialysis therapy. The majority of these patients initially receive a continuous form of dialysis therapy call continuous renal replacement therapy (CRRT). Prior studies have suggested that higher CRRT dose-intensity improved health outcomes for these patients; however, this was not found in high-quality clinical trials. These more recent trials suggested a lower range of dose-intensity compared with the higher range as the new standard of care. This was incorporated into guidelines. To date, no clinical trials have evaluated this lower range and specifically, it is plausible that an even lower dose-intensity of CRRT may be well tolerated, safe, associated with similar outcomes and be more cost-effective. This is the objective of the WISDOM trial, to compare the guideline standard with lower dose-intensity among patients who are started on CRRT in the intensive care unit.
This description comes directly from the study's public registry record.
Sean M Bagshaw, MD · 780-248-1256 · bagshaw@ualberta.ca
Ellen Morrison, PhD · ejmorris@ualberta.ca
Always discuss trial participation with your own doctor first.
| Mayo Clinic | Rochester, Minnesota, United States | Recruiting |
| Foothills Medical Centre | Calgary, Alberta, Canada | Recruiting |
| University of Alberta Hospital | Edmonton, Alberta, Canada | Recruiting |
| Grey Nuns Hospital | Edmonton, Alberta, Canada | Recruiting |
| Sturgeon Community Hospital | St. Albert, Alberta, Canada | Recruiting |
| Hamilton General Hospital | Hamilton, Ontario, Canada | Recruiting |
| Sunnybrook Health Sciences Centre | North York, Ontario, Canada | Recruiting |
| St Michael's Hospital | Toronto, Ontario, Canada | Recruiting |
| Regina General Hospital/Saskatchewan Health Authority | Regina, Saskatchewan, Canada | Recruiting |
| Guy's & St Thomas' Hospitals | London, United Kingdom | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06446739