Condition: Gastroesophageal Junction · Gastroesophageal Adenocarcinoma · Esophageal Neoplasms · Sponsor: Merck Sharp & Dohme LLC
This is a phase 1/2 multicenter, open-label umbrella platform study that will evaluate the safety and efficacy of sacituzumab tirumotecan (MK-2870) plus paclitaxel versus ramucirumab plus paclitaxel, and HER3-DXD plus ramucirumab versus ramucirumab plus paclitaxel for the treatment of participants with advanced or metastatic gastric adenocarcinoma, gastroesophageal junction (GEJ) adenocarcinoma, or esophageal adenocarcinoma who have failed 1 prior line of therapy. This is an estimation study, and no formal hypothesis testing will be performed.
This description comes directly from the study's public registry record.
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Always discuss trial participation with your own doctor first.
| University of Arizona Cancer Center-University of Arizona Cancer Center ( Site 8927) | Tucson, Arizona, United States | Recruiting |
| UCLA Hematology/Oncology - Santa Monica ( Site 8905) | Los Angeles, California, United States | Recruiting |
| Norton Cancer Institute - Downtown ( Site 8900) | Louisville, Kentucky, United States | Completed |
| The Cancer and Hematology Centers ( Site 8912) | Grand Rapids, Michigan, United States | Recruiting |
| Hematology-Oncology Associates of Central NY, P.C. ( Site 8925) | East Syracuse, New York, United States | Recruiting |
| Columbia University Irving Medical Center-CUIMC Herbert Irving Comprehensive Cancer Center Clinical ( Site 8907) | New York, New York, United States | Completed |
| UPMC Hillman Cancer Center-UPMC ( Site 8904) | Pittsburgh, Pennsylvania, United States | Recruiting |
| University of Texas MD Anderson Cancer Center ( Site 8920) | Houston, Texas, United States | Recruiting |
| Liga Norte Riograndense Contra o Câncer ( Site 8303) | Natal, Rio Grande do Norte, Brazil | Recruiting |
| Hospital Nossa Senhora da Conceição ( Site 8301) | Porto Alegre, Rio Grande do Sul, Brazil | Recruiting |
| IBCC - Instituto Brasileiro de Controle do Câncer ( Site 8304) | São Paulo, São Paulo, Brazil | Recruiting |
| ICESP - INSTITUTO DO CÂNCER DO ESTADO DE SÃO PAULO ( Site 8300) | São Paulo, Brazil | Recruiting |
+ 35 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT06445972