Condition: Colorectal Cancer · CRC · Pancreatic Ductal Adenocarcinoma · Sponsor: Revolution Medicines, Inc.
The purpose of this platform study is to evaluate the safety, tolerability, pharmacokinetics (PK), and preliminary antitumor activity of novel RAS(ON) inhibitors combined with Standard(s) of Care (SOC) or with novel agents. The current subprotocols include the following: Subprotocol A: RMC-6236 + 5-fluorouracil-based regimens Subprotocol B: RMC-6236 + cetuximab with or without mFOLFOX6 Subprotocol C: RMC-6236 + gemcitabine + nab-paclitaxel Subprotocol D: RMC-9805 with or without RMC-6236 + 5-fluorouracil-based regimens Subprotocol E: RMC-9805 with or without RMC-6236 + cetuximab with or without mFOLFOX6 Subprotocol F: RMC-9805 with or without RMC-6236 + gemcitabine + nab-paclitaxel
This description comes directly from the study's public registry record.
Revolution Medicines · 1-844-2-REVMED · medinfo@revmed.com
Always discuss trial participation with your own doctor first.
| Ironwood Cancer and Research Centers | Chandler, Arizona, United States | Recruiting |
| Mayo Clinic Hospital | Phoenix, Arizona, United States | Recruiting |
| HonorHealth Research Institute | Scottsdale, Arizona, United States | Recruiting |
| UC San Diego Moores Cancer Center | La Jolla, California, United States | Recruiting |
| Cedars-Sinai Cancer at Cedars-Sinai Medical Center | Los Angeles, California, United States | Recruiting |
| UCLA Hematology/Oncology- Santa Monica | Los Angeles, California, United States | Recruiting |
| University of Colorado Hospital-Anschutz Cancer Pavilion | Aurora, Colorado, United States | Recruiting |
| Yale-New Haven Hospital-Yale Cancer Center | New Haven, Connecticut, United States | Recruiting |
| Mayo Clinic Cancer Center | Jacksonville, Florida, United States | Recruiting |
| Moffitt Cancer Center | Tampa, Florida, United States | Recruiting |
| The University of Kansas Clinical Research Center | Westwood, Kansas, United States | Recruiting |
| The Sidney Kimmel Comprehensive Cancer Center at John Hopkins | Baltimore, Maryland, United States | Recruiting |
+ 20 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT06445062