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Study identifier: NCT06442566 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

ACTION: Trial of Adding Buprenorphine, CBT, and TMS to Improve Outcomes of Long-Term Opioid Therapy for Chronic Pain

Condition: Opioid Withdrawal · Chronic Pain  ·  Sponsor: Medical University of South Carolina

PhasePhase 1/Phase 2
Planned participants240
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersYes

About this study

This study will sequentially evaluate three novel and scalable interventions for at-risk individuals on long term opioid therapy for chronic pain: (1) low-dose transdermal buprenorphine initiation without a period of opioid withdrawal; (2) a brief Cognitive Behavioral Intervention for pain (CBI); and (3) "accelerated" rTMS over the left dorsolateral prefrontal cortex, by examining standardized repeated measures of clinical outcomes at baseline, during treatment, and at 4-, 12-, 24- and 52-week follow-up.

This description comes directly from the study's public registry record.

Talk to the study team

Kelly Barth  ·  843-792-0686  ·  stephen@musc.edu

Rafael Mendoza  ·  mendozra@musc.edu

Always discuss trial participation with your own doctor first.

Locations (1)

Medical University of South CarolinaCharleston, South Carolina, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT06442566