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Study identifier: NCT06440135 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Ziftomenib Maintenance Post Allo-HCT

Condition: Acute Myeloid Leukemia · Acute Myeloid Leukemia in Remission · NPM1 Mutation  ·  Sponsor: Massachusetts General Hospital

PhasePhase 1
Planned participants22
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The purpose of this study is to test the safety, effects, and recommended dose of an investigational drug, ziftomenib, in addition to the standard treatment on blood cancer with Allogeneic Hematopoietic Cell Transplantation (allo-HCT). This study plans to learn more about ziftomenib, which targets and inhibits negative interactions within cancer cells related to AML, when given after allo-HCT, to determine if it improves outcomes following allo-HCT. The name of the study drug involved in this study is: • Ziftomenib

This description comes directly from the study's public registry record.

Talk to the study team

Zachariah DeFilipp, MD  ·  (617) 726-5765  ·  zdefilipp@mgh.harvard.edu

Always discuss trial participation with your own doctor first.

Locations (2)

Massachusetts General HospitalBoston, Massachusetts, United StatesRecruiting
Ohio State University Wexner Medical Center- James Cancer HospitalColumbus, Ohio, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT06440135