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Study identifier: NCT06439082 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

A Study to Investigate the Efficacy and Safety of Crizanlizumab (5 mg/kg) Compared With Placebo in Adolescent and Adult Sickle Cell Disease Patients Who Experience Frequent Vaso-Occlusive Crises (SPARKLE)

Condition: Sickle Cell Disease  ·  Sponsor: Novartis Pharmaceuticals

PhasePhase 3
Planned participants354
Who can joinAll sexes, 12 Years to 100 Years
Healthy volunteersNo

About this study

A phase III, multi-center, randomized, placebo-controlled, double-blind study to assess efficacy and safety of crizanlizumab (5 mg/kg) versus placebo, with or without hydroxyurea/hydroxycarbamide therapy, in adolescent and adult Sickle Cell Disease patients with frequent vaso-occlusive crises.

This description comes directly from the study's public registry record.

Talk to the study team

Novartis Pharmaceuticals  ·  1-888-669-6682  ·  novartis.email@novartis.com

Novartis Pharmaceuticals  ·  +41613241111

Always discuss trial participation with your own doctor first.

Locations (32)

University Of AlabamaBirmingham, Alabama, United StatesRecruiting
Ctr for Inherited Blood DisordersOrange, California, United StatesRecruiting
Childrens National HospitalWashington D.C., District of Columbia, United StatesRecruiting
University of FloridaJacksonville, Florida, United StatesRecruiting
Augusta University GeorgiaAugusta, Georgia, United StatesRecruiting
WCG Sonar Clinical ResearchRiverdale, Georgia, United StatesRecruiting
Norton Children s HospitalLouisville, Kentucky, United StatesRecruiting
The Johns Hopkins University School of MedicineBaltimore, Maryland, United StatesRecruiting
Southern Specialty ResearchFlowood, Mississippi, United StatesRecruiting
Childrens Hospital at MontefioreThe Bronx, New York, United StatesRecruiting
East Carolina UniversityGreenville, North Carolina, United StatesRecruiting
Wake Forest University Baptist Medical CenterWinston-Salem, North Carolina, United StatesRecruiting

+ 20 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT06439082