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Study identifier: NCT06435429 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

A Study Comparing the Efficacy and Safety of Zanidatamab to Trastuzumab, Each in Combination With Physician's Choice Chemotherapy, for the Treatment of Participants With Metastatic HER2-positive Breast Cancer

Condition: Metastatic HER2-positive Breast Cancer  ·  Sponsor: Jazz Pharmaceuticals

PhasePhase 3
Planned participants550
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The efficacy and safety of zanidatamab in combination with physician's choice of chemotherapy compared with trastuzumab in combination with physician's choice of chemotherapy will be evaluated for the treatment of participants with metastatic HER2-positive breast cancer who have progressed on, or are intolerant to, previous T-DXd treatment.

This description comes directly from the study's public registry record.

Talk to the study team

Clinical Trial Disclosure & Transparency  ·  215-832-3750  ·  ClinicalTrialDisclosure@JazzPharma.com

Always discuss trial participation with your own doctor first.

Locations (166)

Mayo Clinic Scottsdale - PPDSPhoenix, Arizona, United StatesRecruiting
Arizona Oncology Tucson - WilmotTucson, Arizona, United StatesWithdrawn
University of Arizona Cancer CenterTucson, Arizona, United StatesRecruiting
The Oncology Institute Of Hope And InnovationCerritos, California, United StatesRecruiting
Los Angeles Hematology Oncology Medical Group GlendaleGlendale, California, United StatesRecruiting
USC-Norris Comprehensive Cancer Center - Investigational Drug Service IDSLos Angeles, California, United StatesRecruiting
UCSF at Mission Bay MBSan Francisco, California, United StatesRecruiting
University of Colorado-Cancer Center-PPDSAurora, Colorado, United StatesRecruiting
Rocky Mountain Cancer CentersDenver, Colorado, United StatesRecruiting
Medstar Georgetown University HospitalWashington D.C., District of Columbia, United StatesRecruiting
Washington Cancer CenterWashington D.C., District of Columbia, United StatesRecruiting
Florida Cancer Specialists Research SouthFort Myers, Florida, United StatesRecruiting

+ 154 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT06435429