Condition: Type 1 Diabetes · Heart Failure · Sponsor: University of Dundee
People with type 1 diabetes sometimes develop heart failure which can cause symptoms like breathlessness, tiredness or ankle swelling, reduced quality of life and lead to being admitted to hospital or suffering potential fatal consequences. This trial is investigating if a tablet called sotagliflozin, can improve quality of life in people with type 1 diabetes and heart failure. In addition, this trial will also assess the safety and tolerability of sotagliflozin in this population. In previous trials that included people with type 2 diabetes and heart failure sotagliflozin was shown to improve patients' symptoms of heart failure, quality of life and reduce the chance of people with heart failure being admitted to hospital or dying. However, people with type 1 diabetes and heart failure were not included in these trials meaning that it is not known if these benefits also apply to this population. This trial aims to recruit 320 people with type 1 diabetes and heart failure symptoms in multiple sites in the United Kingdom (UK). This trial will compare the health and quality of life of participants who take sotagliflozin tablets with participants who take placebo tablets, which is a dummy tablet that looks the same as sotagliflozin. Participants will be randomly allocated to one of two groups (i.e. one taking sotagliflozin and the other the placebo) and both the medical team and participants will not know in which group each participant is until the end of the study. Participan…
This description comes directly from the study's public registry record.
Ify Mordi, MBChB, MD · +44 1382 385591 · i.mordi@dundee.ac.uk
Always discuss trial participation with your own doctor first.
| Aberdeen Royal Infirmary | Aberdeen, United Kingdom | Recruiting |
| Addenbrookes Hospital | Cambridge, United Kingdom | Recruiting |
| Ninewells Hospital | Dundee, United Kingdom | Recruiting |
| Royal Infirmary of Edinburgh | Edinburgh, United Kingdom | Recruiting |
| Glasgow Royal Infirmary, Glasgow Clinical Research Facility | Glasgow, United Kingdom | Recruiting |
| Leicester General Hospital | Leicester, United Kingdom | Recruiting |
| Aintree University Hospital | Liverpool, United Kingdom | Recruiting |
| Prince Philip Hospital | Llanelli, United Kingdom | Recruiting |
| Guy's Hospital | London, United Kingdom | Recruiting |
| St George's University Hospitals NHS Foundation Trust | London, United Kingdom | Recruiting |
| Manchester Royal Infirmary Hospital | Manchester, United Kingdom | Recruiting |
| North Manchester General Hospital | Manchester, United Kingdom | Recruiting |
+ 5 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT06435156