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Study identifier: NCT06434363 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Phase I/II Study of AD-PluReceptor Plus Tafasitamab-cxix and Lymphodepleting Chemotherapy in Patients With Autoimmune Disorders

Condition: Autoimmune Disorders · Systemic Sclerosis · Systemic Lupus Erythematosus  ·  Sponsor: M.D. Anderson Cancer Center

PhasePhase 1/Phase 2
Planned participants47
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The goal of Safety Lead-In is to confirm the safety of tafasitamab when given to patients with SSc, SLE, and LN. The goal of Phase 1 is to find the recommended dose of AD-PluReceptor-NK cells in combination with tafasitamab and lymphodepleting chemotherapy that can be given to patients with the disease. The goal of Phase 2 is to learn if the dose of AD-PluReceptor-NK cells found in Phase 1 in combination with tafasitamab and lymphodepleting chemotherapy can help to control the disease.

This description comes directly from the study's public registry record.

Talk to the study team

Chitra Chitra Hosing, MD  ·  (713) 745-3219  ·  cmhosing@mdanderson.org

Always discuss trial participation with your own doctor first.

Locations (2)

MD Anderson Cancer CenterHouston, Texas, United StatesRecruiting
The University of Texas Health Science Center at HoustonHouston, Texas, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT06434363