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Study identifier: NCT06430528 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

A Block-and-Replace Therapy With Osilodrostat and Concomitant Glucocorticoid Replacement

Condition: Endogenous Cushing Syndrome · Adrenal Insufficiency · Hypercortisolism  ·  Sponsor: University of Michigan

PhaseN/A
Planned participants12
Who can joinAll sexes, 18 Years to 75 Years
Healthy volunteersNo

About this study

The major goal of this study is to determine the incidence of adrenal insufficiency in patients with endogenous Cushing syndrome receiving osilodrostat treatment combined with a replacement of glucocorticoid (block-and-replace approach). The investigators are also evaluating new biomarker steroids to reflect adequate osilodrostat dosing, the durability and safety, and clinical improvement during treatment.

This description comes directly from the study's public registry record.

Talk to the study team

Richard Auchus  ·  734-764-7764  ·  rauchus@med.umich.edu

Thaira Blanco Varela  ·  734-647-5661  ·  tbv@med.umich.edu

Always discuss trial participation with your own doctor first.

Locations (1)

University of MichiganAnn Arbor, Michigan, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT06430528