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Study identifier: NCT06430385 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

ATTUNE: A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Intrathecally-Administered ION440 in Participants With Methyl CpG Binding Protein 2 (MECP2) Duplication Syndrome (MDS)

Condition: Methyl CpG Binding Protein 2 (MECP2) Duplication Syndrome  ·  Sponsor: Ionis Pharmaceuticals, Inc.

PhasePhase 1/Phase 2
Planned participants48
Who can joinMale, 2 Years to 65 Years
Healthy volunteersNo

About this study

The primary purpose of this study is to evaluate the safety and tolerability of ION440.

This description comes directly from the study's public registry record.

Talk to the study team

Ionis Pharmaceuticals  ·  (844) 779-1497  ·  IonisMECP2study@clinicaltrialmedia.com

Always discuss trial participation with your own doctor first.

Locations (11)

Rady Children's HospitalSan Diego, California, United StatesRecruiting
University of Colorado Hopsital - Anschutz Medical CampusAurora, Colorado, United StatesRecruiting
Kennedy KriegerBaltimore, Maryland, United StatesRecruiting
Boston Children's HospitalBoston, Massachusetts, United StatesRecruiting
Gillette Children's Specialty HealthcareSaint Paul, Minnesota, United StatesRecruiting
Children's Hospital of PhiladelphiaPhiladelphia, Pennsylvania, United StatesRecruiting
Vanderbilt University Medical CenterNashville, Tennessee, United StatesRecruiting
Baylor College of MedicineHouston, Texas, United StatesRecruiting
Kepler University HospitalLinz, AustriaRecruiting
CHU Dijon BourgogneDijon, FranceRecruiting
Hospital Saint Joan de DeuBarcelona, SpainRecruiting

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Source record: clinicaltrials.gov/study/NCT06430385