● Recruiting

A Phase 1 Study of BGB-B2033, Alone or in Combination With Tislelizumab With or Without Bevacizumab, in Participants With Advanced or Metastatic Solid Tumors

Condition: Metastatic Hepatocellular Carcinoma · Local Advanced Hepatocellular Carcinoma · Alpha-fetoprotein (AFP)-Producing Gastric Cancer · Sponsor: BeOne Medicines

PhasePhase 1

Planned participants392

Who can joinAll sexes, 18 Years to no upper limit

Healthy volunteersNo

About this study

This is a first-in-human (FIH) clinical study designed to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and anti-tumor activity of BGB-B2033 administered as monotherapy and in combination with tislelizumab, with or without bevacizumab. The study will enroll participants with locally advanced or metastatic hepatocellular carcinoma (HCC), alpha-fetoprotein (AFP)-producing gastric cancer (GC), extragonadal yolk sac tumors/non-dysgerminomas, or glypican-3 (GPC3)-positive squamous non-small cell lung cancer (NSCLC).

This description comes directly from the study's public registry record.

Talk to the study team

Study Director · 1.877.828.5568 · clinicaltrials@beonemed.com

Always discuss trial participation with your own doctor first.

Locations (47)

City of Hope Phoenix Cancer Center	Goodyear, Arizona, United States	Recruiting
City of Hope National Medical Center	Duarte, California, United States	Recruiting
City of Hope Chicago Cancer Center	Zion, Illinois, United States	Recruiting
Memorial Sloan Kettering Cancer Center Mskcc	New York, New York, United States	Recruiting
Upmc Hillman Cancer Center(Univ of Pittsburgh)	Pittsburgh, Pennsylvania, United States	Recruiting
Scri Oncology Partners	Nashville, Tennessee, United States	Recruiting
The University of Texas Md Anderson Cancer Center	Houston, Texas, United States	Recruiting
Centro Gaucho Integrado de Oncologia Hospital Mae de Deus	Porto Alegre, Brazil	Recruiting
Hospital Da Bahia	Salvador, Brazil	Recruiting
Fundacao Faculdade Regional de Medicina de Sao Jose Do Rio Preto	São José do Rio Preto, Brazil	Recruiting
Anhui Provincial Hospital	Hefei, Anhui, China	Recruiting
Chongqing University Cancer Hospital	Chongqing, Chongqing Municipality, China	Recruiting

+ 35 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT06427941