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Study identifier: NCT06424288 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

A Study to Test Whether Vicadrostat in Combination With Empagliflozin Helps People With Heart Failure

Condition: Heart Failure  ·  Sponsor: Boehringer Ingelheim

PhasePhase 3
Planned participants6000
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This study is open to adults aged 18 or above legal age with heart failure. People can join the study if they have heart failure symptoms and a left ventricular ejection fraction (LVEF) of 40% or more. The purpose of this study is to find out whether vicadrostat (BI 690517) in combination with empagliflozin helps people with heart failure. Participants are put into 2 groups by chance. Every participant has an equal chance of being in each group. The groups are: * Vicadrostat/empagliflozin group: participants take vicadrostat/empagliflozin as tablets once a day. * Placebo/empagliflozin group: participants take placebo/empagliflozin as tablets once a day. Participants can stay in the study as long as they benefit from treatment and can tolerate it. During this time, they visit their doctors regularly. The doctors regularly check participants' health and take note of any unwanted effects. The study staff may also contact the participants by phone. Participants also regularly answer questions about their well-being. The study does not have a fixed duration. It continues until there is enough data to see if the treatment is working.

This description comes directly from the study's public registry record.

Talk to the study team

Boehringer Ingelheim  ·  1-800-243-0127  ·  lintriage.rdg@boehringer-ingelheim.com

Always discuss trial participation with your own doctor first.

Locations (652)

Diagnostic and Medical ClinicMobile, Alabama, United StatesNot Yet Recruiting
Mobile Heart Specialists, PCMobile, Alabama, United StatesRecruiting
Velocity Clinical Research-Chula VistaChula Vista, California, United StatesRecruiting
University of California IrvineOrange, California, United StatesNot Yet Recruiting
North America Research InstituteSan Dimas, California, United StatesRecruiting
Amicis Research Center - ValenciaSanta Clarita, California, United StatesRecruiting
Orange County Research CenterTustin, California, United StatesRecruiting
Bridgeport HospitalBridgeport, Connecticut, United StatesNot Yet Recruiting
Excel Medical Clinical TrialsBoca Raton, Florida, United StatesRecruiting
Bay Area CardiologyBrandon, Florida, United StatesRecruiting
Clearwater Cardiovascular and Interventional ConsultantsClearwater, Florida, United StatesRecruiting
Cardiology Associates Research Co.Daytona Beach, Florida, United StatesRecruiting

+ 640 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT06424288