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Study identifier: NCT06422403 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

A Value-Driven Study on Reducing Immune Checkpoint Inhibitor Dosing Frequency in Advanced Cancers

Condition: Carcinoma, Hepatocellular · Gastric Adenocarcinoma · GastroEsophageal Cancer  ·  Sponsor: National University Hospital, Singapore

PhasePhase 2
Planned participants360
Who can joinAll sexes, 21 Years to 99 Years
Healthy volunteersNo

About this study

This study is a prospective, open label, multi-centre phase 2 trial which assesses the efficacy and safety of standard dosing compared to extended dosing interval of nivolumab, atezolizumab or pembrolizumab in advanced/unresectable gastric/gastroesophageal junction/oesphageal adenocarcinomas with PDL1 CPS ≥5%, hepatocellular carcinoma andnon-small cell lung cancer with PDL1 TPS≥50% with no prior treatment. The investigators hypothesize that nivolumab, pembrolizumab and atezolizumab can be used efficiently at extended dosing intervals, compared to their approved labels with comparable clinical outcome.

This description comes directly from the study's public registry record.

Talk to the study team

Wei Peng Yong  ·  +65 6908 2222  ·  Wei_Peng_YONG@nuhs.edu.sg

Always discuss trial participation with your own doctor first.

Locations (1)

Department of Hematology-Oncology, National University HospitaSingapore, SingaporeRecruiting

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Source record: clinicaltrials.gov/study/NCT06422403