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Study identifier: NCT06421298 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

A Prospective, Single-arm, Phase II Clinical Trial to Evaluate the Efficacy and Safety of Tafolecimab and Sintilimab Combined With Chemotherapy in Patients With Advanced or Metastatic Driver Gene-negative Non-small Cell Lung Cancer After Failure of First-line Immunotherapy.

Condition: Lung Cancer  ·  Sponsor: Jinghui Wang

PhasePhase 2
Planned participants30
Who can joinAll sexes, 18 Years to 75 Years
Healthy volunteersNo

About this study

The second-line treatment for patients who have progressed after first-line immune checkpoint inhibitor therapy, is chemotherapy based on docetaxel and other drugs. The treatment effect is limited. The median survival time of them are 6 months. So there is a huge unmet medical need. This study is a Prospective, Single-arm, Phase II Clinical Trial to Evaluate the Efficacy and Safety of Tafolecimab and Sintilimab Combined With Chemotherapy in Patients With Advanced or Metastatic Driver Gene-negative Non-small Cell Lung Cancer After Failure of First-line Immunotherapy. 30 patients will be enrolled. The main endpoint is PFS,and the secondary endpoint are OS,DCR,DOR,ORR, and so on.

This description comes directly from the study's public registry record.

Talk to the study team

Jinghui Wang  ·  13683128239  ·  jinghuiwang2006@163.com

Always discuss trial participation with your own doctor first.

Locations (1)

Beijing Chest Hospital, Capital Medical UniversityBeijing, Beijing Municipality, ChinaRecruiting

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Source record: clinicaltrials.gov/study/NCT06421298