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Study identifier: NCT06420492 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Study of Novel Therapeutics for Acute Remedy of Colitis

Condition: Ulcerative Colitis · Ulcerative Colitis Chronic Moderate · Ulcerative Colitis Chronic Severe  ·  Sponsor: Brigham and Women's Hospital

PhasePhase 2
Planned participants20
Who can joinAll sexes, 18 Years to 75 Years
Healthy volunteersNo

About this study

This study is a clinical trial being done to investigate the efficacy of drug BRS201 as a treatment in patients with acute ulcerative colitis. Patients who qualify are adults who have not responded to treatments for their severe ulcerative colitis. Participation in this study will take 12 weeks long and the study is structured as an open-label pilot study in which participants will take the study drug for 4 weeks in the form of an oral medication. Participation may also involve receiving an IV dose of the medication. The study will require participants to attend 8 study visits, all of which will be conducted at a study site. Participation will involve taking an oral medication twice daily, tracking the medication in a log, and getting blood drawn and giving a stool and urine sample for a few lab tests throughout the study. Participants may also undergo a flexible sigmoidoscopy at the beginning and end of the study.

This description comes directly from the study's public registry record.

Talk to the study team

Joshua Korzenik, MD  ·  617 732-6389  ·  jkorzenik@bwh.harvard.edu

Siani Ellis  ·  617-396-7703  ·  sellis13@bwh.harvard.edu

Always discuss trial participation with your own doctor first.

Locations (2)

Brigham and Women's HospitalChestnut Hill, Massachusetts, United StatesNot Yet Recruiting
Brigham and Women's HospitalChestnut Hill, Massachusetts, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT06420492