Condition: Splenectomy · Sponsor: Assistance Publique - Hôpitaux de Paris
Human splenic physiology remains poorly understood due to lack of functional exploration. However, through its ability to recognize alterations or modifications in circulating cells and to trigger an innate and adaptive response in response to these anomalies, the spleen plays a central role in several diseases affecting blood cells, directly or indirectly. The analysis of the splenic clearance of abnormal cells during ex-vivo perfusions made it possible to clarify the pathogenesis of malaria and the role of the spleen in the adaptive immune response. The study's investigative team wishes to extend these explorations to other human diseases in which the spleen is involved, and to evaluate the preventive or curative potential of substances that can modify the perception of blood cells by the spleen (e.g. monoclonal antibodies directed against circulating cells, among other options).
This description comes directly from the study's public registry record.
Pierre Buffet, MD, PhD · pierre.buffet@aphp.fr
Hélène Morel · 1 71 49 63 46 · helene.morel@aphp.fr
Always discuss trial participation with your own doctor first.
| Hôpital Beaujon | Clichy, France | Recruiting |
| Hôpital Saint Antoine | Paris, France | Recruiting |
| Hôpital Pitié Salpêtrière | Paris, France | Recruiting |
| Hôpital Necker-Enfants Malades | Paris, France | Recruiting |
| Institut Pasteur | Paris, France | Active Not Recruiting |
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Source record: clinicaltrials.gov/study/NCT06418256