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Study identifier: NCT06414148 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

MRD-Directed Consolidation With Epcor-only or Epcor-R2 Post Anti-CD19 CAR TCell Therapy for Large B-Cell Lymphoma

Condition: Relapsed/Refractory Large B-cell Lymphoma  ·  Sponsor: Peter MacCallum Cancer Centre, Australia

PhasePhase 2
Planned participants40
Who can joinAll sexes, 16 Years to no upper limit
Healthy volunteersNo

About this study

This is a Phase II open-label, two-arm randomised non-comparative, multi-centre study to evaluate the efficacy of Epcor-only (Epcoritamab alone) or Epcor-R2 (Epcoritamab, lenalidomide and rituximab) as consolidation post anti-CD19 CAR T-cell therapy for patients that have responded by conventional criteria but who are at high risk of progression by virtue of being Minimal Residual Disease (MRD) positive as determined by a Circulating Tumour DNA (ctDNA) assay.

This description comes directly from the study's public registry record.

Talk to the study team

Contact details are listed per location below or on the registry record.

Always discuss trial participation with your own doctor first.

Locations (6)

Royal Prince Alfred HospitalCamperdown, New South Wales, AustraliaNot Yet Recruiting
Westmead HospitalWestmead, New South Wales, AustraliaRecruiting
Royal Brisbane and Women's HospitalHerston, Queensland, AustraliaNot Yet Recruiting
Alfred HospitalMelbourne, Victoria, AustraliaRecruiting
Peter MacCallum Cancer CentreMelbourne, Victoria, AustraliaRecruiting
Fiona Stanley HospitalMurdoch, Western Australia, AustraliaNot Yet Recruiting

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Source record: clinicaltrials.gov/study/NCT06414148