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Study identifier: NCT06413680 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

A First-In Human (FIH) Study to Find Out How Well REGN10597 Medicine Given Alone or in Combination With Cemiplimab Works in Adult Participants Who Have Cancer With Tumors That Have Spread in Their Body

Condition: Melanoma · Clear-Cell Renal-Cell Carcinoma (ccRCC) · Advanced Solid Tumors  ·  Sponsor: Regeneron Pharmaceuticals

PhasePhase 1/Phase 2
Planned participants240
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This study is researching an experimental drug called REGN10597 alone or in combination with another drug called cemiplimab (called "study drug(s)"). The study is focused on patients with certain solid tumors that are in an advanced stage. The aim of the study is to see how safe, tolerable, and effective the study drug(s) are. The study is looking at several other research questions, including: * What side effects may happen from taking the study drug(s) * How much study drug(s) is in the blood at different times * Whether the body makes antibodies against the study drug(s) (which could make the study drug(s) less effective or could lead to side effects)

This description comes directly from the study's public registry record.

Talk to the study team

Clinical Trials Administrator  ·  844-734-6643  ·  clinicaltrials@regeneron.com

Always discuss trial participation with your own doctor first.

Locations (11)

USC Norris Comprehensive Cancer CenterLos Angeles, California, United StatesRecruiting
University of California San Francisco (UCSF)San Francisco, California, United StatesRecruiting
Yale School of MedicineNorth Haven, Connecticut, United StatesRecruiting
University of ChicagoChicago, Illinois, United StatesRecruiting
Start Midwest Cancer ResearchGrand Rapids, Michigan, United StatesRecruiting
Northwell HealthLake Success, New York, United StatesRecruiting
University of North Carolina at Chapel HillChapel Hill, North Carolina, United StatesRecruiting
University of Pittsburgh Medical Center - Hillman Cancer CenterPittsburgh, Pennsylvania, United StatesRecruiting
MD Anderson Cancer CenterHouston, Texas, United StatesRecruiting
Next OncologySan Antonio, Texas, United StatesRecruiting
The Start Center for Cancer CareSan Antonio, Texas, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT06413680