Condition: Severe Aplastic Anemia · Acquired Amegakaryocytic Thrombocytopenia · Acquired Pure Red Cell Aplasia · Sponsor: Masonic Cancer Center, University of Minnesota
A phase II trial of a reduced intensity conditioned (RIC) allogeneic hematopoietic cell transplant (HCT) with post-transplant cyclophosphamide (PTCy) for idiopathic severe aplastic anemia (SAA), paroxysmal nocturnal hemoglobinuria (PNH), acquired pure red cell aplasia (aPRCA), or acquired amegakaryocytic thrombocytopenia (aAT) utilizing population pharmacokinetic (popPK)-guided individual dosing of pre-transplant conditioning and differential dosing of low dose total body irradiation based on age, presence of myelodysplasia and/or clonal hematopoiesis.
This description comes directly from the study's public registry record.
Meera Srikanthan, MD · (612) 626-2961 · srika038@umn.edu
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| University of Minnesota Masonic Cancer Center | Minneapolis, Minnesota, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06412497