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Study identifier: NCT06411691 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

KRAS-Targeted Vaccine Combined With Balstilimab and Botensilimab for Patients With Stage IV MMR-p Colorectal Cancer and Pancreatic Ductal Cancer

Condition: Colorectal Cancer · Pancreatic Cancer  ·  Sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

PhasePhase 1
Planned participants54
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

Phase 1b study evaluating the efficacy and immune response to a synthetic long peptide mutant KRAS vaccine (SPL mKRASvax) combined with Balstilimab and Botensilimab for unresectable or metastatic mismatch repair-proficient (MMR-p) colorectal cancer (mCRC) or unresectable or metastatic MMR-p pancreatic ductal adenocarcinoma (PDAC) patients with measurable disease following first-line chemotherapy.

This description comes directly from the study's public registry record.

Talk to the study team

Colleen Apostol, RN  ·  410-614-3644  ·  GIClinicalTrials@jhmi.edu

Always discuss trial participation with your own doctor first.

Locations (1)

Sidney Kimmel Comprehensive Cancer CenterBaltimore, Maryland, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT06411691