Condition: Epithelioid Hemangioendothelioma · Sarcoma,Soft Tissue · Sponsor: Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Epithelioid hemangioendothelioma (EHE) is an ultra-rare sarcoma, marked by distinctive molecular and pathological features and with a variable clinical behavior. Its natural history is still partially understood, reliable prognostic and predictive factors are lacking and many questions are still open on the optimal management. In the context of EURACAN, a prospective registry specifically dedicated to EHE was developed and launched with the aim of providing, through high-quality prospective data collection, a better understanding of this disease. The study design is a registry-based cohort study including only new cases of patients with a pathological and molecularly confirmed diagnosis of EHE. The objectives are to improve the understanding of EHE natural history, validate and identify new prognostic and predictive factors, clarify the activity and efficacy of currently available treatment options, describe treatment pattern. It is an hospital-based registry established in centres with expertise in EHE including adult patients with a new pathological and molecularly confirmed diagnosis of EHE starting from the 1st December 2023. The characteristics of each patient in the facility who meets the above-mentioned inclusion criteria will be collected prospectively and longitudinally with follow-up at cancer progression and / or cancer relapse or patient death. The data analyses will include descriptive statistics and analytical analyses. Multivariable Cox's proportional hazar…
This description comes directly from the study's public registry record.
Annalisa Trama, MD · 02 2390 3535 · annalisa.trama@istitutotumori.mi.it
Melissa Gil Sanjines · 02 2390 3564 · melissa.gilsanjines@istitutotumori.mi.it
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| University Hospital Graz | Graz, Graz, Austria | Recruiting |
| Aarhus University Hospital | Aarhus, Aarhus, Denmark | Recruiting |
| Léon Bérard Center | Lyon, Lyon, France | Recruiting |
| Centre Oscar Lambret | Lille, France | Not Yet Recruiting |
| Essen University Hospital | Essen, Hesse, Germany | Recruiting |
| Campus Großhadern | München, Germany | Not Yet Recruiting |
| Istituto Ortopedico Rizzoli | Bologna, Bologna, Italy | Recruiting |
| Azienda Ospedaliero Universitaria Careggi | Careggi, Firenze, Italy | Recruiting |
| IRCCS Istituto Clinica Humanitas | Rozzano, Milano, Italy | Recruiting |
| Fondazione IRCCS Istituto Nazionale dei Tumori | Milan, Milan, Italy | Recruiting |
| Istituto Oncologico Veneto | Padova, Padova, Italy | Recruiting |
| Policlinico Universitario P. Giaccone | Palermo, Palermo, Italy | Recruiting |
+ 10 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT06408441