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Study identifier: NCT06406114 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Optimizing the Diagnostic Approach to Cephalosporin Allergy Testing

Condition: Drug Allergy · Cephalosporin Allergy · Drug Hypersensitivity  ·  Sponsor: Massachusetts General Hospital

PhasePhase 2
Planned participants300
Who can joinAll sexes, 18 Years to 70 Years
Healthy volunteersNo

About this study

Cephalosporin antibiotics are commonly used but can result in allergic reactions and anaphylaxis. There is no clear diagnostic approach for cephalosporin-allergic patients, and guidance for the use of other antibiotics in allergic patients is based on side chain chemical similarity and limited skin testing evidence. This project includes a clinical trial and mechanistic studies to optimize the approach to cephalosporin allergy and advance future diagnostics.

This description comes directly from the study's public registry record.

Talk to the study team

Cara Yelverton, BSc, PhD  ·  6173120387  ·  cyelverton@mgh.harvard.edu

Kell Lopez, BS  ·  6177320589  ·  klopez5@bwh.harvard.edu

Always discuss trial participation with your own doctor first.

Locations (6)

Mayo Clinic ArizonaScottsdale, Arizona, United StatesRecruiting
University of California, San FranciscoSan Francisco, California, United StatesRecruiting
Massachusetts General HospitalBoston, Massachusetts, United StatesRecruiting
Rochester General HospitalRochester, New York, United StatesRecruiting
Vanderbilt University Medical CenterNashville, Tennessee, United StatesRecruiting
University of Texas Southwestern Medical CenterDallas, Texas, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT06406114