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Study identifier: NCT06403267 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

NoNO-42 Trial in Acute Ischemic Stroke Patients Selected for Thrombolysis With or Without Endovascular Thrombectomy

Condition: Acute Ischemic Stroke  ·  Sponsor: NoNO Inc.

PhasePhase 2
Planned participants600
Who can joinAll sexes, 18 Years to 90 Years
Healthy volunteersNo

About this study

ACT-42 is a domain of the ACT-GLOBAL platform (NCT06352632). This trial is a Phase 2b, multicenter, prospective, randomized, open label, blinded-endpoint (PROBE) controlled single-dose adaptive trial. A total of up to 600 male and female participants aged ≥ 18 to ≤ 90 years harboring an acute ischemic stroke who are eligible for an intravenous thrombolytic with or without endovascular thrombectomy therapy will be enrolled within 4.5 hours of stroke onset/last known well.

This description comes directly from the study's public registry record.

Talk to the study team

Michael Tymianski, MD PhD  ·  416-583-1687  ·  mtymianski@nonoinc.ca

Always discuss trial participation with your own doctor first.

Locations (9)

University of Calgary - Foothills Medical CentreCalgary, Alberta, CanadaRecruiting
University of Alberta HospitalEdmonton, Alberta, CanadaRecruiting
Vancouver General HospitalVancouver, British Columbia, CanadaRecruiting
University of ManitobaWinnipeg, Manitoba, CanadaRecruiting
Hamilton General HospitalHamilton, Ontario, CanadaRecruiting
Ottawa Hospital Research InstituteOttawa, Ontario, CanadaRecruiting
Sunnybrook Health Sciences CentreToronto, Ontario, CanadaRecruiting
Unity Health Toronto, St. Michael's HospitalToronto, Ontario, CanadaRecruiting
Royal University HospitalSaskatoon, Saskatchewan, CanadaRecruiting

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Source record: clinicaltrials.gov/study/NCT06403267