Condition: Atrial Fibrillation · Left Atrial Appendage Absent · Anticoagulant Adverse Reaction · Sponsor: Odense University Hospital
Left atrial appendage (LAA) closure has become a frequent addition to oral anticoagulation in patients with atrial fibrillation who undergo cardiac surgery. The procedure significantly reduces the risk of stroke and systemic embolism, which may render anticoagulation unnecessary or even harmful when considering the associated increased risk of bleeding. A clinical trial to address the need for anticoagulation after LAA closure is needed. The ATLAAC trial will enroll 1220 patients with atrial fibrillation who have previously undergone surgical LAA closure. Patients will undergo a cardiac CT-scan to determine if LAA closure was successful and patients with successful closure will be randomized to continue or discontinue anticoagulation. The trial will assess the risk of ischemic stroke, peripheral arterial embolism, and major bleeding during the randomized intervention
This description comes directly from the study's public registry record.
Kristina Gosvig, M.D. · +4551520696 · kristina.gosvig@rsyd.dk
Julie Goller, M.D. · 22951855 · julie.goller@outlook.com
Always discuss trial participation with your own doctor first.
| Rigshospitalet | Copenhagen, Capital Region, Denmark | Not Yet Recruiting |
| Gentofte Hospital | Gentofte Municipality, Capital Region, Denmark | Recruiting |
| Regionshospital Gødstrup | Herning, Central Jutland, Denmark | Not Yet Recruiting |
| Aalborg university hospital | Aalborg, North Denmark, Denmark | Not Yet Recruiting |
| Århus Universitetshospital | Aarhus, Region Midt, Denmark | Recruiting |
| Odense University Hospital | Odense, Region Syddanmark, Denmark | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06401616