Condition: Chronic Rhinosinusitis With Nasal Polyps · Chronic Rhinosinusitis Without Nasal Polyps · Sponsor: Medical University of Vienna
The investigators aim to investigate two major so far unresolved topics in CRSwNP research: (1) Thorough functional and molecular characterisation of barrier function in patients suffering from CRSsNP and CRSwNP and (2) effect of dupilumab treatment on barrier function in polyp patients. This will be achieved in patient-derived samples by employing measurement of barrier function in primary cell cultures in combination with a mass cytometry based imaging approach, transcriptomic analysis as well as cytokine and microbiome data of individual patients.
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| Medical University of Vienna | Vienna, Austria, Austria | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06398873