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Study identifier: NCT06398639 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Polygenic Risk Stratification Combined With mpMRI to Identify Clinically Relevant Prostate Cancer

Condition: Prostate Cancer · Polygenic Risk Score  ·  Sponsor: Adam S. Kibel, MD

PhaseNA
Planned participants1500
Who can joinMale, 40 Years to 69 Years
Healthy volunteersYes

About this study

The goal of this clinical trial is to evaluate a screening method to detect clinically relevant prostate cancer. This clinical trial is using genetic data to determine a man's risk of cancer, together with multiparametric magnetic resonance imaging (mpMRI) to identify men with higher grade cancer. The main questions it aims to answer are: * If genetic data related to prostate cancer used with MRI can identify higher-grade, potentially fatal prostate cancer * What age a MRI is useful clinically for prostate cancer screening * If deep learning methods used with MRI when the genetic risk of the man is known can more accurately predict significant cancers Participants will: * Get a prostate specific antigen (PSA) blood test * Get an mpMRI * Get the results of their genetic data to determine if they are considered high-, intermediate-, or low-risk for prostate cancer based on the trials genetic testing * Follow-up for this trial based on the participants risk and findings from the PSA test and mpMRI

This description comes directly from the study's public registry record.

Talk to the study team

Adam S Kibel, MD, MHCM  ·  (617) 525-7697  ·  akibel@bwh.harvard.edu

Daniella Furtado  ·  (617) 525-8782  ·  dfurtado1@bwh.harvard.edu

Always discuss trial participation with your own doctor first.

Locations (5)

Howard University HospitalWashington D.C., District of Columbia, United StatesNot Yet Recruiting
National Cancer InstituteBethesda, Maryland, United StatesNot Yet Recruiting
Walter Reed National Military Medical CenterBethesda, Maryland, United StatesNot Yet Recruiting
Massachusetts General HospitalBoston, Massachusetts, United StatesRecruiting
Brigham and Women's HospitalBoston, Massachusetts, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT06398639