Condition: Atrial Fibrillation · Sponsor: Mahidol University
Atrial fibrillation (AF) is a leading cause of cardiovascular mortality and morbidity. Asian patients with AF have a higher rate of major bleeding including intracranial hemorrhage (ICH) compared to non-Asians. Non-vitamin K antagonist oral anticoagulants (NOACs) are the safer drugs compared to warfarin due to a lower rate of ICH, but the rate of NOACs use in many Asian AF is much lower than non-Asian countries due to economic concerns. The purpose of the COhort of antithrOmbotic use and cLinical outcomes in patients with Atrial Fibrillation (COOL-AF) Phase 2 registry is to determine the changes in antithrombotic patterns and the impact on clinical outcomes. The COOL-AF Phase 2 study is a prospective observational multicenter study of patients with known or newly diagnosed non-valvular AF in Thailand. The aim is a sample size is 3680 patients from 33 centers within a 2-years enrollment timeline. Patients will be follow-up every 6 months until 3 years. The study outcomes were death, ischemic stroke/systemic embolism, major bleeding, myocardial infarction, heart failure, and quality of life.
This description comes directly from the study's public registry record.
Pontawee Kaewcomdee, B.N.S · 0815594286 · pontawee.k@gmail.com
Rungroj Krittayaphong, MD,FESC,FACC · 092-2071250 · rungroj.kri@mahidol.ac.th
Always discuss trial participation with your own doctor first.
| Faculty of Meddcine Siriraj Hospital, Mahidol University | Bangkok, Bangkok, Thailand | Recruiting |
| Faculty of Medicine, Chulalongkorn University, | Bangkok, Bangkok, Thailand | Recruiting |
| Faculty of Medicine, Ramathibodi Hospital, Mahidol University | Bangkok, Bangkok, Thailand | Recruiting |
| Faculty of Medicine, Vajira Hospital, Navamindradhiraj University | Bangkok, Bangkok, Thailand | Recruiting |
| Phramongkutklao College of Medicine | Bangkok, Bangkok, Thailand | Not Yet Recruiting |
| Police General Hospital | Bangkok, Bangkok, Thailand | Not Yet Recruiting |
| Central Chest Institute of Thailand | Nonthaburi, Changwat Nonthaburi, Thailand | Recruiting |
| Faculty of Medicine, Prince of Songkla University | Songkhla, Changwat Songkhla, Thailand | Recruiting |
| Faculty of Medicine, Chiang Mai University, | Chiang Mai, Chiang Mai, Thailand | Recruiting |
| Bhumibol Adulyadej Hospital | Bangkok, Thailand | Recruiting |
| Charoen Krung Pracha Rak Hospital | Bangkok, Thailand | Recruiting |
| Rajavithi Hospital | Bangkok, Thailand | Not Yet Recruiting |
+ 21 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT06396299