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Study identifier: NCT06395103 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Substudy 01A: Zilovertamab Vedotin in Pediatric and Young Adult Participants With Hematologic Malignancies or Solid Tumors (MK-9999-01A/LIGHTBEAM-U01)

Condition: B-cell Acute Lymphoblastic Leukemia · Diffuse Large B-cell Lymphoma · Burkitt Lymphoma  ·  Sponsor: Merck Sharp & Dohme LLC

PhasePhase 1/Phase 2
Planned participants90
Who can joinAll sexes, 6 Months to 25 Years
Healthy volunteersNo

About this study

Substudy 01A is part of a platform study. The purpose of this study is to assess the efficacy and safety of zilovertamab vedotin in pediatric participants with relapsed or refractory B-cell acute lymphoblastic leukemia (B-ALL), diffuse large B-cell lymphoma (DLBCL)/Burkitt lymphoma, or neuroblastoma and in pediatric and young adult participants with Ewing sarcoma.

This description comes directly from the study's public registry record.

Talk to the study team

Toll Free Number  ·  1-888-577-8839  ·  Trialsites@msd.com

Always discuss trial participation with your own doctor first.

Locations (71)

Children's Hospital Los Angeles ( Site 1006)Los Angeles, California, United StatesRecruiting
Children's Hospital Colorado-Center for Cancer and Blood Disorders ( Site 1016)Aurora, Colorado, United StatesRecruiting
Yale New Haven Hospital ( Site 1012)New Haven, Connecticut, United StatesRecruiting
Johns Hopkins All Children's Hospital ( Site 1025)St. Petersburg, Florida, United StatesRecruiting
University of Iowa-Holden Comprehensive Cancer Center ( Site 1017)Iowa City, Iowa, United StatesRecruiting
Dana-Farber Cancer Institute ( Site 1013)Boston, Massachusetts, United StatesRecruiting
Corewell Health ( Site 1001)Grand Rapids, Michigan, United StatesRecruiting
Children's Mercy Hospital ( Site 1024)Kansas City, Missouri, United StatesRecruiting
Rutgers Cancer Institute of New Jersey ( Site 1008)New Brunswick, New Jersey, United StatesRecruiting
Memorial Sloan Kettering Cancer Center ( Site 1010)New York, New York, United StatesRecruiting
New York Medical College ( Site 1023)Valhalla, New York, United StatesRecruiting
Sanford Fargo Medical Center-Roger Maris Cancer Center ( Site 1003)Fargo, North Dakota, United StatesRecruiting

+ 59 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT06395103