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Study identifier: NCT06394804 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

A Study of Avutometinib, Defactinib, and Letrozole in People With Low-Grade Serous Ovarian Cancer

Condition: Low-Grade Serous Ovarian Cancer  ·  Sponsor: Memorial Sloan Kettering Cancer Center

PhasePhase 2
Planned participants20
Who can joinFemale, 18 Years to no upper limit
Healthy volunteersNo

About this study

The researchers are doing this study to find out whether the combination of avutometinib, defactinib, and letrozole is an effective treatment for people with low-grade serous ovarian cancer (LGSOC). The researchers will also look at the safety of this combination.

This description comes directly from the study's public registry record.

Talk to the study team

Rachel Grisham, MD  ·  646-888-4653  ·  medgmoclinicaltrials@mskcc.org

Chrisann Kyi, MD  ·  646-888-4221

Always discuss trial participation with your own doctor first.

Locations (8)

Emory Winship Cancer InstituteAtlanta, Georgia, United StatesRecruiting
Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities)Basking Ridge, New Jersey, United StatesRecruiting
Memorial Sloan Kettering Monmouth (Limited Protocol Activities)Middletown, New Jersey, United StatesRecruiting
Memorial Sloan Kettering Bergen (Limited Protocol Activities)Montvale, New Jersey, United StatesRecruiting
Memorial Sloan Kettering Suffolk -Commack (Limited Protocol Activities)Commack, New York, United StatesRecruiting
Memorial Sloan Kettering Westchester (Limited Protocol Activities)East White Plains, New York, United StatesRecruiting
Memorial Sloan Kettering Cancer CenterNew York, New York, United StatesRecruiting
Memorial Sloan Kettering Nassau (Limited Protocol Activities)Uniondale, New York, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT06394804