Condition: Triple-Negative Breast Cancer · Sponsor: Merck Sharp & Dohme LLC
This is a randomized, open-label study comparing the efficacy and safety of adjuvant sacituzumab tirumotecan (MK-2870) in combination with pembrolizumab compared to treatment of physician's choice (TPC) in participants with triple-negative breast cancer (TNBC) who received neoadjuvant therapy and did not achieve a pathological complete response (pCR) at surgery. The primary objective is to compare sacituzumab tirumotecan plus pembrolizumab to TPC (pembrolizumab or pembrolizumab plus capecitabine) with respect to invasive disease-free survival (iDFS) per investigator assessment. It is hypothesized that sacituzumab tirumotecan plus pembrolizumab is superior to TPC with respect to iDFS per investigator assessment.
This description comes directly from the study's public registry record.
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| Infirmary Cancer Care ( Site 0001) | Mobile, Alabama, United States | Recruiting |
| Ironwood Cancer & Research Centers-Research ( Site 0054) | Chandler, Arizona, United States | Recruiting |
| MemorialCare Orange Coast Medical Center ( Site 9501) | Fountain Valley, California, United States | Recruiting |
| Scripps Cancer Center ( Site 0052) | La Jolla, California, United States | Recruiting |
| Cancer and Blood Specialty Clinic ( Site 0008) | Los Alamitos, California, United States | Completed |
| Kaiser Permanente - Oakland ( Site 0079) | Oakland, California, United States | Recruiting |
| Profound Research LLC ( Site 0105) | Oceanside, California, United States | Recruiting |
| Kaiser Permanente - Roseville ( Site 0081) | Roseville, California, United States | Recruiting |
| Kaiser Permanente - San Francisco ( Site 0080) | San Francisco, California, United States | Recruiting |
| Kaiser Permanente - Santa Clara ( Site 0082) | Santa Clara, California, United States | Recruiting |
| Providence Medical Foundation ( Site 9543) | Santa Rosa, California, United States | Recruiting |
| Kaiser Permanente Vallejo Medical Center ( Site 0060) | Vallejo, California, United States | Recruiting |
+ 294 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT06393374