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Study identifier: NCT06388226 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Leg Heat Therapy in Heart Failure With Preserved Ejection Fraction

Condition: Heart Failure With Preserved Ejection Fraction  ·  Sponsor: Indiana University

PhaseNA
Planned participants90
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The objective of this pilot study is to establish evidence to support the validity of HT in improving skeletal muscle function and physical capacity of patients with HFpEF. Our central hypothesis is that HT treatment will lead to improvements in skeletal muscle and microvascular function compared to a control intervention. As a result, we anticipate that patients treated with HT will demonstrate improved skeletal muscle microvascular blood flow and oxygenation resulting in enhanced exercise tolerance. To explore this hypothesis, we propose the following specific aim: Explore the effects of home-based HT on exercise tolerance in patients with HFpEF.

This description comes directly from the study's public registry record.

Talk to the study team

Doris Muriathiri, MPH, CCRP  ·  317-274-0903  ·  dmuriath@iu.edu

Daniel Hirai, PhD  ·  765-494-7113  ·  dhirai@purdue.edu

Always discuss trial participation with your own doctor first.

Locations (2)

IU Health MethodistIndianapolis, Indiana, United StatesRecruiting
IU Health University HospitalIndianapolis, Indiana, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT06388226