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Study identifier: NCT06387069 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

A Study to Evaluate HMPL-306 in Patients With IDH1or IDH2-mutated Acute Myeloid Leukemia

Condition: Acute Myeloid Leukemia  ·  Sponsor: Hutchmed

PhasePhase 3
Planned participants316
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This study is a multicenter, randomized, open-label, phase III clinical study (RAPHAEL) to evaluate the efficacy, safety, and PK of HMPL-306 versus salvage chemotherapy in patients with R/R AML harboring IDH1 and IDH2 mutations.

This description comes directly from the study's public registry record.

Talk to the study team

Erin Lou, Doctor  ·  +86 21 2067 1942  ·  erinl@hutch-med.com

Yu Wang, Bachelor  ·  (+86) 18058125909  ·  yuwang@hutch-med.com

Always discuss trial participation with your own doctor first.

Locations (53)

Anhui Provincial Hospital(The First Affiliated Hospital of U STC)Hefei, Anhui, ChinaRecruiting
The First Affiliated Hospital of Anhui Medical UniversityHefei, Anhui, ChinaRecruiting
The Second Hospital of Anhui Medical UniversityHefei, Anhui, ChinaRecruiting
Peking University People's HospitalBeijing, Beijing Municipality, ChinaRecruiting
The First Affiliated Hospital of Chongqing Medical UniversityChongqing, Chongqing Municipality, ChinaRecruiting
Fujian Medical University Union HospitalFuzhou, Fujian, ChinaRecruiting
The First Affilated Hospital of Fujian Medical UniversityFuzhou, Fujian, ChinaRecruiting
Quanzhou First Hospital Affiliated to Fujian Medical UniversityQuanzhou, Fujian, ChinaRecruiting
The First Affiliated Hospital of Xiamen UniversityXiamen, Fujian, ChinaRecruiting
Sun Yat-sen University Cancer CenterGuangzhou, Guangdong, ChinaRecruiting
Guangzhou First People's HospitalGuangzhou, Guangdong, ChinaRecruiting
Nanfang Hospital,Southern Medical UniversityGuanzhou, Guangdong, ChinaRecruiting

+ 41 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT06387069