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Study identifier: NCT06384651 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Intraosseous vs. Intravenous Vancomycin Administration in Total Ankle Arthroplasty

Condition: Infections · Ankle Arthritis  ·  Sponsor: The Methodist Hospital Research Institute

PhasePhase 4
Planned participants40
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The purpose of this study is to compare two different antibiotic regimens and techniques during total ankle arthroplasty (TAA). Primary Objective: Comparable levels of vancomycin will be found in bone, soft tissue, and systemic samples between patient groups. Secondary Objective: Compare 30 day and 90 day post-operative complication rates (infection) between the control (standard IV administration of vancomycin) vs the interventional group (intraosseous administration of vancomycin). The investigators hypothesize that there will be no difference in complication (infection) rates between groups.

This description comes directly from the study's public registry record.

Talk to the study team

Thomas C Sullivan, BS  ·  346-238-1603  ·  tsullivan@houstonmethodist.org

Blesson Varghese, BS  ·  713-441-3814  ·  bvarghese6@houstonmethodist.org

Always discuss trial participation with your own doctor first.

Locations (1)

Houston Methodist HospitalHouston, Texas, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT06384651