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Study identifier: NCT06384560 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Neoadjuvant Triple Therapy for (Borderline) Resectable Pancreatic Cancer (PREOPANC-5)

Condition: Localized Pancreatic Adenocarcinoma · Borderline Resectable Pancreatic Adenocarcinoma · Resectable Pancreatic Adenocarcinoma  ·  Sponsor: Amsterdam UMC, location VUmc

PhasePhase 1/Phase 2
Planned participants66
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

Since patients with (borderline) resectable pancreatic cancer have a limited life expectancy, it is important to improve treatment strategies. Therefore, the objective of this study is to investigate whether neoadjuvant triple treatment with chemotherapy (mFOLFIRINOX), immunotherapy (pembrolizumab and stereotactic radiotherapy, followed by adjuvant surgery and chemotherapy and immunotherapy, improves survival in patients with (borderline) resectabel pancreatic cancer.

This description comes directly from the study's public registry record.

Talk to the study team

J. W. Wilmink, MD, PhD  ·  +31 204444321  ·  j.w.wilmink@amsterdamumc.nl

A. M. Gehrels, MD, MA  ·  a.gehrels@amsterdamumc.nl

Always discuss trial participation with your own doctor first.

Locations (4)

Amsterdam University Medical CenterAmsterdam, NetherlandsRecruiting
Maastricht University Medical CenterMaastricht, NetherlandsNot Yet Recruiting
St. Antonius ZiekenhuisNieuwegein, NetherlandsRecruiting
Erasmus University Medical CenterRotterdam, NetherlandsRecruiting

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Source record: clinicaltrials.gov/study/NCT06384560