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Study identifier: NCT06380530 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Advanced Surgical Simulation Processes in the Correction of Skeletal Defects and Deformities

Condition: Musculoskeletal Deformity · Musculoskeletal Abnormalities · Musculoskeletal Disorder  ·  Sponsor: Istituto Ortopedico Rizzoli

PhaseNA
Planned participants100
Who can joinAll sexes, 2 Years to 40 Years
Healthy volunteersNo

About this study

Virtual Surgical Planning (VSP), Computer-Aided Surgical Simulation (CASS) for bone corrections, and the customization of implants and devices through 3D printing, known as Patient-Specific Instruments (PSI) and Graft-Specific Instruments (GSI), are assuming increasingly central roles in orthopedic clinical and surgical practice. One area witnessing notable advancement is the treatment of musculoskeletal disorders (MMS) in children, adolescents, and young adults. These disorders involve severe and rare abnormalities in skeletal formation and development across three-dimensional planes, often affecting multiple limbs. Managing such deformities is complex, challenging to standardize, and prone to unpredictable clinical, radiographic, and functional outcomes. The application of 3D modeling and printing technologies offers a deeper understanding of deformities and facilitates improved prediction, precision, reproducibility, and safety in surgical interventions. The Musculoskeletal Apparatus Network (RAMS Network) centers are equipped with advanced 3D laboratories for surgical simulation and planning, aligned with the overarching goal of improving surgery quality through "in-silico" medicine (ISM) principles. At present, numerous complex surgeries involving Virtual Surgical Planning (VSP) and sterilizable 3D-printed Patient-Specific Instruments (PSI) and/or Graft-Specific Instruments (GSI) are being simulated and performed at the Rizzoli Institute. Preliminary data from previo…

This description comes directly from the study's public registry record.

Talk to the study team

Grazia Chiara Menozzi  ·  0516366  ·  graziachiara.menozzi@ior.it

Giovanni Trisolino, MD  ·  0516366  ·  giovanni.trisolino@ior.it

Always discuss trial participation with your own doctor first.

Locations (7)

IRCCS Istituto Ortopedico RizzoliBologna, BO, ItalyRecruiting
Istituto Clinico HumanitasRozzano, MI, ItalyNot Yet Recruiting
Istituto Giannina GasliniGenova, ItalyNot Yet Recruiting
Galeazzi Orthopedic InstituteMilan, ItalyNot Yet Recruiting
Policlinico San MatteoPavia, ItalyNot Yet Recruiting
Istituto Nazionale Tumori Regina ElenaRoma, ItalyNot Yet Recruiting
Ospedale Pediatrico Bambino GesùRoma, ItalyNot Yet Recruiting

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Source record: clinicaltrials.gov/study/NCT06380530