Condition: Sedentary Behavior · Metabolic Syndrome · Age-related Cognitive Decline · Sponsor: University of Nottingham
Life expectancy has been increasing for the last 150 years, but the maintenance of health has not kept pace with increased lifespan, and on average, UK adults spend the last decade of life in poor-health, with major consequences for society and the individual. Persistent physical inactivity is thought to be a key contributing factor to the risk of poor health and functional decline occurring in middle-aged and older adults. It is therefore concerning that most middle-aged adults spend \>8hrs/day being sedentary, with average step count of 3000-4000 steps/day. To be able to holistically assess the effectiveness of future strategies to address age-related decline in health, and devise public health messages to help individuals reach older age in better health, it is essential that the complex physiological effects that activity and inactivity have across biological systems are characterised. The goal of this intervention study is to compare the impact of physical activity and inactivity on body functioning. Twenty moderately active participants will decrease their physical activity for three months to match the average amount carried out by middle-aged people in the UK. They will then undertake 3-months of reconditioning training to restore their fitness. In addition, twenty sedentary participants will increase their physical activity to UK recommended levels for six months. Before and at points during the intervention period, participants will be asked to make some measure…
This description comes directly from the study's public registry record.
Paul L Greenhaff (PI), PhD · +44 (0) 1158230133 · paul.greenhaff@nottingham.ac.uk
Melanie Tooley (participant recruitment), BSc · +44 (0) 115 9515151 · melanie.marshall@nottingham.ac.uk
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| David Greenfield Human Physiology Unit | Nottingham, Notts, United Kingdom | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06377254