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Study identifier: NCT06374524 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Greater Occipital Nerve Block for Spontaneous Intracranial Hypotension

Condition: Spontaneous Intracranial Hypotension  ·  Sponsor: University Health Network, Toronto

PhaseN/A
Planned participants34
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

Spontaneous Intracranial Hypotension (SIH) is a debilitating neurological disorder caused by a cerebrospinal fluid leak (CSF), with an estimated incidence of 5 per 100,000 persons per year, of which mostly women between the ages of 35 years and 55 years. The typical presentation is moderate-to-severe orthostatic headache and several other possible neurological symptoms, that significantly impact patients' quality of life. Treatment of SIH usually starts with conservative measures, consisting of strict supine bed rest, hydration, caffeine, and simple analgesics. The vast majority of patients will require invasive treatments for their CSF leak, such as epidural blood patches, fibrin glue patches, endovascular coiling, and/or surgical repair. These specialized treatments are only offered in tertiary care centers and require specialized personnel and resources, which implicates a certain waiting time for the patients before permanent treatment is offered. In the meantime, due to the lack of an effective and accessible alternative, patients continue to suffer. The greater occipital nerve block (GONB) has been reported as a simple, safe, and effective treatment to provide short-to-intermediate term relief of migraine, cervicogenic headache, cluster headache, occipital neuralgia, and more recently, post-dural puncture headaches (PDPH). As the pathophysiology of intracranial hypotension caused by SIH or PDPH is very similar, it is stipulated that the effect of GONB will be similar …

This description comes directly from the study's public registry record.

Talk to the study team

Anna Kalleitner, RN  ·  416-603-5800  ·  Anna.Kalleitner@uhn.ca

Always discuss trial participation with your own doctor first.

Locations (1)

Toronto Western HospitalToronto, Ontario, CanadaRecruiting

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Source record: clinicaltrials.gov/study/NCT06374524